;; Cerebellar Purkinje Cell: resurgent Na current and high frequency ;; firing (Khaliq et al 2003). (nemo-model K1 ((input v (cai from ion-pools) (ica from ion-currents)) (const ena = 60) (const ek = -88) (const ca0 = 1e-4) (component (type gate-complex) (name K1) ;; HH TEA-sensitive Purkinje potassium current (component (type gate) ;; constants ;; rate functions (K1_v = (v + 11)) ;; account for junction potential (K1_minf = (let ((mivh -24) (mik 15.4)) (1 / (1 + exp (neg (K1_v - mivh) / mik))))) (K1_mtau = (let ((mty0 0.00012851) (mtvh1 100.7) (mtk1 12.9) (mtvh2 -56.0) (mtk2 -23.1)) (1e3 * (if (K1_v < -35) then (3.0 * (3.4225e-5 + 0.00498 * exp (neg (K1_v) / -28.29))) else (mty0 + 1.0 / (exp ((K1_v + mtvh1) / mtk1) + exp ((K1_v + mtvh2) / mtk2))) )))) (K1_hinf = (let ((hiy0 0.31) (hiA 0.78) (hivh -5.802) (hik 11.2)) (hiy0 + hiA / (1 + exp ((K1_v - hivh) / hik))))) (K1_htau = (1e3 * (if ( K1_v > 0 ) then (0.0012 + 0.0023 * exp (-0.141 * K1_v)) else (1.2202e-05 + 0.012 * exp (neg (((K1_v - (-56.3)) / 49.6) ^ 2)))))) (hh-ionic-gate (K1 ;; ion name: exported variables will be of the form {ion}_{id} (initial-m (K1_minf)) (initial-h (K1_hinf)) (m-power 3) (h-power 1) (m-inf (K1_minf)) (m-tau (K1_mtau)) (h-inf (K1_hinf)) (h-tau (K1_htau)))) ) (component (type pore) (const gbar_K1 = 0.004) (output gbar_K1 )) (component (type permeating-ion) (name k) (const e_K1 = ek) (output e_K1 )) ) ;; end K1 current ))