CGC_KM_defs = "CGC_KM.m" ; autoload ("CGC_KM" , CGC_KM_defs) ; autoload ("CGC_KM_init" , CGC_KM_defs) ; CGC_KM_init ; y0 = CGC_KM_init (-65) ; global N ; N = length (y0) ; function is = CGC_KM_currents_odepkg (y) global N ; global i_KM ; t = y (1) ; s = y (2:N+1) ; y1 = CGC_KM (t , s) ; is = [ t i_KM ] ; endfunction function is = CGC_KM_currents_lsode (y) global N ; global i_KM ; t = y (1) ; s = y (2:N+1) ; y1 = CGC_KM (s , t) ; is = [ t i_KM ] ; endfunction function ys = CGC_KM_vclamp_run1_odepkg (N , dt , vchold , vchdur , vcbase , vcdur) global reltol abstol P = odeset ("RelTol" , reltol , "AbsTol" , abstol , "MaxStep" , 1 , "InitialStep" , dt) ; t0 = 0.0 ; t1 = t0+vchdur ; t2 = t1 ; t3 = t2+vcdur ; t4 = t3 ; t5 = t4+vchdur ; vinit = vchold ; y0 = CGC_KM_init (vinit) sol = ode2r (@CGC_KM , [ t0 t1 ] , y0 , P) ; ys = [ sol.x sol.y ] ; vinit = vcbase ; y0 = sol.y (size (sol.y) (1) , :) ' ; y0 (1) = vinit sol = ode2r (@CGC_KM , [ t2 t3 ] , y0 , P) ; ys = vertcat (ys , [ sol.x sol.y ]) ; vinit = vchold ; y0 = sol.y (size (sol.y) (1) , :) ' ; y0 (1) = vinit sol = ode2r (@CGC_KM , [ t4 t5 ] , y0 , P) ; ys = vertcat (ys , [ sol.x sol.y ]) ; endfunction ; function ys = CGC_KM_vclamp_run1_lsode (N , dt , vchold , vchdur , vcbase , vcdur) global reltol abstol lsode_options ("absolute tolerance" , abstol) ; lsode_options ("relative tolerance" , reltol) ; lsode_options ("integration method" , "bdf") ; lsode_options ("initial step size" , dt) ; t0 = 0.0 ; t1 = t0+vchdur ; thold0 = linspace (t0 , t1 , (t1-t0) /dt) ; t2 = t1 ; t3 = t2+vcdur ; tclamp = linspace (t2 , t3 , (t3-t2) /dt) ; t4 = t3 ; t5 = t4+vchdur ; thold1 = linspace (t4 , t5 , (t5-t4) /dt) ; vinit = vchold ; y0 = CGC_KM_init (vinit) y = lsode (@CGC_KM , y0 , thold0) ; ys = [ thold0' y ] ; vinit = vcbase ; y0 = y (size (y) (1) , :) ' ; y0 (1) = vinit y = lsode (@CGC_KM , y0 , tclamp) ; ys = vertcat (ys , [ tclamp' y ]) ; vinit = vchold ; y0 = y (size (y) (1) , :) ' ; y0 (1) = vinit y = lsode (@CGC_KM , y0 , thold1) ; ys = vertcat (ys , [ thold1' y ]) ; endfunction function ilog = CGC_KM_vclamp_fn (N , dt , vchold , vchdur , vcbase , vcdur , vcinc , vcsteps) vc = vcbase ; ys = cell (1 , vcsteps) ; for i = 1:vcsteps y = CGC_KM_vclamp_run1_lsode (N , dt , vchold , vchdur , vc , vcdur) ; ys (i) = y ; vc = vc + vcinc ; endfor ; ilog = cell (vcsteps , 1) ; for i = 1:vcsteps ilogv = [ ] ; n = size (ys {i}) (1) ; for j = 1:n next = CGC_KM_currents_lsode (ys {i} (j , :)) ; ilogv = vertcat (ilogv , next) ; endfor ; ilog {i} = ilogv ; endfor ; endfunction global reltol abstol reltol = 1e-03 ; abstol = 1e-03 ; dt = 0.001 ; ## i_KM plot i_KM_index = 2 ; global comp235_vchold comp235_vchdur comp235_vcbase comp235_vcbdur comp235_vcinc comp235_vcsteps CGC_KM_ilog = CGC_KM_vclamp_fn (N , dt , comp235_vchold , comp235_vchdur , comp235_vcbase , comp235_vcbdur , comp235_vcinc , comp235_vcsteps) ; subplot (1 , 3 , 1) ; plot (CGC_KM_ilog{1}(:,1) , CGC_KM_ilog{1}(:,i_KM_index) , CGC_KM_ilog{2}(:,1) , CGC_KM_ilog{2}(:,i_KM_index) , CGC_KM_ilog{3}(:,1) , CGC_KM_ilog{3}(:,i_KM_index) , CGC_KM_ilog{4}(:,1) , CGC_KM_ilog{4}(:,i_KM_index) , CGC_KM_ilog{5}(:,1) , CGC_KM_ilog{5}(:,i_KM_index) , CGC_KM_ilog{6}(:,1) , CGC_KM_ilog{6}(:,i_KM_index) , CGC_KM_ilog{7}(:,1) , CGC_KM_ilog{7}(:,i_KM_index) , CGC_KM_ilog{8}(:,1) , CGC_KM_ilog{8}(:,i_KM_index)) ; KM_log = vertcat ([CGC_KM_ilog{1}(:,1),CGC_KM_ilog{1}(:,i_KM_index)] , [CGC_KM_ilog{2}(:,1),CGC_KM_ilog{2}(:,i_KM_index)] , [CGC_KM_ilog{3}(:,1),CGC_KM_ilog{3}(:,i_KM_index)] , [CGC_KM_ilog{4}(:,1),CGC_KM_ilog{4}(:,i_KM_index)] , [CGC_KM_ilog{5}(:,1),CGC_KM_ilog{5}(:,i_KM_index)] , [CGC_KM_ilog{6}(:,1),CGC_KM_ilog{6}(:,i_KM_index)] , [CGC_KM_ilog{7}(:,1),CGC_KM_ilog{7}(:,i_KM_index)] , [CGC_KM_ilog{8}(:,1),CGC_KM_ilog{8}(:,i_KM_index)]) ; save -ascii "KM.dat" KM_log ;