CGC_Kir_defs = "CGC_Kir.m" ; autoload ("CGC_Kir" , CGC_Kir_defs) ; autoload ("CGC_Kir_init" , CGC_Kir_defs) ; CGC_Kir_init ; y0 = CGC_Kir_init (-65) ; global N ; N = length (y0) ; function is = CGC_Kir_currents_odepkg (y) global N ; global i_Kir ; t = y (1) ; s = y (2:N+1) ; y1 = CGC_Kir (t , s) ; is = [ t i_Kir ] ; endfunction function is = CGC_Kir_currents_lsode (y) global N ; global i_Kir ; t = y (1) ; s = y (2:N+1) ; y1 = CGC_Kir (s , t) ; is = [ t i_Kir ] ; endfunction function ys = CGC_Kir_vclamp_run1_odepkg (N , dt , vchold , vchdur , vcbase , vcdur) global reltol abstol P = odeset ("RelTol" , reltol , "AbsTol" , abstol , "MaxStep" , 1 , "InitialStep" , dt) ; t0 = 0.0 ; t1 = t0+vchdur ; t2 = t1 ; t3 = t2+vcdur ; t4 = t3 ; t5 = t4+vchdur ; vinit = vchold ; y0 = CGC_Kir_init (vinit) sol = ode2r (@CGC_Kir , [ t0 t1 ] , y0 , P) ; ys = [ sol.x sol.y ] ; vinit = vcbase ; y0 = sol.y (size (sol.y) (1) , :) ' ; y0 (1) = vinit sol = ode2r (@CGC_Kir , [ t2 t3 ] , y0 , P) ; ys = vertcat (ys , [ sol.x sol.y ]) ; vinit = vchold ; y0 = sol.y (size (sol.y) (1) , :) ' ; y0 (1) = vinit sol = ode2r (@CGC_Kir , [ t4 t5 ] , y0 , P) ; ys = vertcat (ys , [ sol.x sol.y ]) ; endfunction ; function ys = CGC_Kir_vclamp_run1_lsode (N , dt , vchold , vchdur , vcbase , vcdur) global reltol abstol lsode_options ("absolute tolerance" , abstol) ; lsode_options ("relative tolerance" , reltol) ; lsode_options ("integration method" , "bdf") ; lsode_options ("initial step size" , dt) ; t0 = 0.0 ; t1 = t0+vchdur ; thold0 = linspace (t0 , t1 , (t1-t0) /dt) ; t2 = t1 ; t3 = t2+vcdur ; tclamp = linspace (t2 , t3 , (t3-t2) /dt) ; t4 = t3 ; t5 = t4+vchdur ; thold1 = linspace (t4 , t5 , (t5-t4) /dt) ; vinit = vchold ; y0 = CGC_Kir_init (vinit) y = lsode (@CGC_Kir , y0 , thold0) ; ys = [ thold0' y ] ; vinit = vcbase ; y0 = y (size (y) (1) , :) ' ; y0 (1) = vinit y = lsode (@CGC_Kir , y0 , tclamp) ; ys = vertcat (ys , [ tclamp' y ]) ; vinit = vchold ; y0 = y (size (y) (1) , :) ' ; y0 (1) = vinit y = lsode (@CGC_Kir , y0 , thold1) ; ys = vertcat (ys , [ thold1' y ]) ; endfunction function ilog = CGC_Kir_vclamp_fn (N , dt , vchold , vchdur , vcbase , vcdur , vcinc , vcsteps) vc = vcbase ; ys = cell (1 , vcsteps) ; for i = 1:vcsteps y = CGC_Kir_vclamp_run1_lsode (N , dt , vchold , vchdur , vc , vcdur) ; ys (i) = y ; vc = vc + vcinc ; endfor ; ilog = cell (vcsteps , 1) ; for i = 1:vcsteps ilogv = [ ] ; n = size (ys {i}) (1) ; for j = 1:n next = CGC_Kir_currents_lsode (ys {i} (j , :)) ; ilogv = vertcat (ilogv , next) ; endfor ; ilog {i} = ilogv ; endfor ; endfunction global reltol abstol reltol = 1e-03 ; abstol = 1e-03 ; dt = 0.001 ; ## i_Kir plot i_Kir_index = 2 ; global comp207_vchold comp207_vchdur comp207_vcbase comp207_vcbdur comp207_vcinc comp207_vcsteps CGC_Kir_ilog = CGC_Kir_vclamp_fn (N , dt , comp207_vchold , comp207_vchdur , comp207_vcbase , comp207_vcbdur , comp207_vcinc , comp207_vcsteps) ; subplot (1 , 3 , 1) ; plot (CGC_Kir_ilog{1}(:,1) , CGC_Kir_ilog{1}(:,i_Kir_index) , CGC_Kir_ilog{2}(:,1) , CGC_Kir_ilog{2}(:,i_Kir_index) , CGC_Kir_ilog{3}(:,1) , CGC_Kir_ilog{3}(:,i_Kir_index) , CGC_Kir_ilog{4}(:,1) , CGC_Kir_ilog{4}(:,i_Kir_index) , CGC_Kir_ilog{5}(:,1) , CGC_Kir_ilog{5}(:,i_Kir_index) , CGC_Kir_ilog{6}(:,1) , CGC_Kir_ilog{6}(:,i_Kir_index) , CGC_Kir_ilog{7}(:,1) , CGC_Kir_ilog{7}(:,i_Kir_index) , CGC_Kir_ilog{8}(:,1) , CGC_Kir_ilog{8}(:,i_Kir_index)) ; Kir_log = vertcat ([CGC_Kir_ilog{1}(:,1),CGC_Kir_ilog{1}(:,i_Kir_index)] , [CGC_Kir_ilog{2}(:,1),CGC_Kir_ilog{2}(:,i_Kir_index)] , [CGC_Kir_ilog{3}(:,1),CGC_Kir_ilog{3}(:,i_Kir_index)] , [CGC_Kir_ilog{4}(:,1),CGC_Kir_ilog{4}(:,i_Kir_index)] , [CGC_Kir_ilog{5}(:,1),CGC_Kir_ilog{5}(:,i_Kir_index)] , [CGC_Kir_ilog{6}(:,1),CGC_Kir_ilog{6}(:,i_Kir_index)] , [CGC_Kir_ilog{7}(:,1),CGC_Kir_ilog{7}(:,i_Kir_index)] , [CGC_Kir_ilog{8}(:,1),CGC_Kir_ilog{8}(:,i_Kir_index)]) ; save -ascii "Kir.dat" Kir_log ;