CGC_pNa_defs = "CGC_pNa.m" ; autoload ("CGC_pNa" , CGC_pNa_defs) ; autoload ("CGC_pNa_init" , CGC_pNa_defs) ; CGC_pNa_init ; y0 = CGC_pNa_init (-65) ; global N ; N = length (y0) ; function is = CGC_pNa_currents_odepkg (y) global N ; global i_pNa ; t = y (1) ; s = y (2:N+1) ; y1 = CGC_pNa (t , s) ; is = [ t i_pNa ] ; endfunction function is = CGC_pNa_currents_lsode (y) global N ; global i_pNa ; t = y (1) ; s = y (2:N+1) ; y1 = CGC_pNa (s , t) ; is = [ t i_pNa ] ; endfunction function ys = CGC_pNa_vclamp_run1_odepkg (N , dt , vchold , vchdur , vcbase , vcdur) global reltol abstol P = odeset ("RelTol" , reltol , "AbsTol" , abstol , "MaxStep" , 1 , "InitialStep" , dt) ; t0 = 0.0 ; t1 = t0+vchdur ; t2 = t1 ; t3 = t2+vcdur ; t4 = t3 ; t5 = t4+vchdur ; vinit = vchold ; y0 = CGC_pNa_init (vinit) sol = ode2r (@CGC_pNa , [ t0 t1 ] , y0 , P) ; ys = [ sol.x sol.y ] ; vinit = vcbase ; y0 = sol.y (size (sol.y) (1) , :) ' ; y0 (1) = vinit sol = ode2r (@CGC_pNa , [ t2 t3 ] , y0 , P) ; ys = vertcat (ys , [ sol.x sol.y ]) ; vinit = vchold ; y0 = sol.y (size (sol.y) (1) , :) ' ; y0 (1) = vinit sol = ode2r (@CGC_pNa , [ t4 t5 ] , y0 , P) ; ys = vertcat (ys , [ sol.x sol.y ]) ; endfunction ; function ys = CGC_pNa_vclamp_run1_lsode (N , dt , vchold , vchdur , vcbase , vcdur) global reltol abstol lsode_options ("absolute tolerance" , abstol) ; lsode_options ("relative tolerance" , reltol) ; lsode_options ("integration method" , "bdf") ; lsode_options ("initial step size" , dt) ; t0 = 0.0 ; t1 = t0+vchdur ; thold0 = linspace (t0 , t1 , (t1-t0) /dt) ; t2 = t1 ; t3 = t2+vcdur ; tclamp = linspace (t2 , t3 , (t3-t2) /dt) ; t4 = t3 ; t5 = t4+vchdur ; thold1 = linspace (t4 , t5 , (t5-t4) /dt) ; vinit = vchold ; y0 = CGC_pNa_init (vinit) y = lsode (@CGC_pNa , y0 , thold0) ; ys = [ thold0' y ] ; vinit = vcbase ; y0 = y (size (y) (1) , :) ' ; y0 (1) = vinit y = lsode (@CGC_pNa , y0 , tclamp) ; ys = vertcat (ys , [ tclamp' y ]) ; vinit = vchold ; y0 = y (size (y) (1) , :) ' ; y0 (1) = vinit y = lsode (@CGC_pNa , y0 , thold1) ; ys = vertcat (ys , [ thold1' y ]) ; endfunction function ilog = CGC_pNa_vclamp_fn (N , dt , vchold , vchdur , vcbase , vcdur , vcinc , vcsteps) vc = vcbase ; ys = cell (1 , vcsteps) ; for i = 1:vcsteps y = CGC_pNa_vclamp_run1_lsode (N , dt , vchold , vchdur , vc , vcdur) ; ys (i) = y ; vc = vc + vcinc ; endfor ; ilog = cell (vcsteps , 1) ; for i = 1:vcsteps ilogv = [ ] ; n = size (ys {i}) (1) ; for j = 1:n next = CGC_pNa_currents_lsode (ys {i} (j , :)) ; ilogv = vertcat (ilogv , next) ; endfor ; ilog {i} = ilogv ; endfor ; endfunction global reltol abstol reltol = 1e-03 ; abstol = 1e-03 ; dt = 0.001 ; ## i_pNa plot i_pNa_index = 2 ; global comp251_vchold comp251_vchdur comp251_vcbase comp251_vcbdur comp251_vcinc comp251_vcsteps CGC_pNa_ilog = CGC_pNa_vclamp_fn (N , dt , comp251_vchold , comp251_vchdur , comp251_vcbase , comp251_vcbdur , comp251_vcinc , comp251_vcsteps) ; subplot (1 , 3 , 1) ; plot (CGC_pNa_ilog{1}(:,1) , CGC_pNa_ilog{1}(:,i_pNa_index) , CGC_pNa_ilog{2}(:,1) , CGC_pNa_ilog{2}(:,i_pNa_index) , CGC_pNa_ilog{3}(:,1) , CGC_pNa_ilog{3}(:,i_pNa_index) , CGC_pNa_ilog{4}(:,1) , CGC_pNa_ilog{4}(:,i_pNa_index) , CGC_pNa_ilog{5}(:,1) , CGC_pNa_ilog{5}(:,i_pNa_index) , CGC_pNa_ilog{6}(:,1) , CGC_pNa_ilog{6}(:,i_pNa_index) , CGC_pNa_ilog{7}(:,1) , CGC_pNa_ilog{7}(:,i_pNa_index) , CGC_pNa_ilog{8}(:,1) , CGC_pNa_ilog{8}(:,i_pNa_index) , CGC_pNa_ilog{9}(:,1) , CGC_pNa_ilog{9}(:,i_pNa_index)) ; pNa_log = vertcat ([CGC_pNa_ilog{1}(:,1),CGC_pNa_ilog{1}(:,i_pNa_index)] , [CGC_pNa_ilog{2}(:,1),CGC_pNa_ilog{2}(:,i_pNa_index)] , [CGC_pNa_ilog{3}(:,1),CGC_pNa_ilog{3}(:,i_pNa_index)] , [CGC_pNa_ilog{4}(:,1),CGC_pNa_ilog{4}(:,i_pNa_index)] , [CGC_pNa_ilog{5}(:,1),CGC_pNa_ilog{5}(:,i_pNa_index)] , [CGC_pNa_ilog{6}(:,1),CGC_pNa_ilog{6}(:,i_pNa_index)] , [CGC_pNa_ilog{7}(:,1),CGC_pNa_ilog{7}(:,i_pNa_index)] , [CGC_pNa_ilog{8}(:,1),CGC_pNa_ilog{8}(:,i_pNa_index)] , [CGC_pNa_ilog{9}(:,1),CGC_pNa_ilog{9}(:,i_pNa_index)]) ; save -ascii "pNa.dat" pNa_log ;