;; Simoes de Souza FM and De Schutter E (2011) Robustness effect of
;; gap junctions between Golgi cells on cerebellar cortex
;; oscillations.  Neural Systems & Circuits 1:7.

(nemo-model Golgi

  (
   (input v celsius)

   (const F = 96485.3)
   (const R = 8.31342)

   (component (type defaults) 
      (const V_t = -35)
      (const celsius = 23)
      (output celsius V_t)
      )

   (component (type membrane-capacitance)
  	 (const c = 1e-3)
	 (output c  ))

   (component (type decaying-pool) (name ca)

      (input (ica from ion-currents))

      (const  d       = .2)
      (const  cao     = 2.)
      (const  cai0    = 5e-5)
      (const  beta    = 1.3)
      
      (d (ca) =  ((neg (ica) / (2 * F * d)) * 1e4 -
		  (beta * (ca - cai0)))
	 (initial cai0))
      
      (output ca cao)
      )


   (component (type decaying-pool) (name ca2)

      (input (ica2 from ion-currents))

      (const valence  = 2)
      (const  d       = .2)
      (const  ca2o    = 2.)
      (const  ca2i0   = 5e-5)
      (const  beta    = 1.3)
      
      (d (ca2) =  ((neg (ica2) / (2 * F * d)) * 1e4 -
		   (beta * (ca2 - ca2i0)))
	 (initial ca2i0))
      
      (output ca2 ca2o valence)
      )


   (component (type decaying-pool) (name na)

      (input (ina from ion-currents))

      (const  d       = .2)
      (const  nao0    = 140.)
      (const  nai0    = 5.)
      (const  beta    = 0.075)
      
      (d (nai) =  ((neg (ina) / (2 * F * d)) * 1e4 - (beta * (nai - nai0)))
	 (initial nai0))
      
      (d (nao) =  ((ina / (2 * F * d)) * 1e4 - (beta * (nao - nao0)))
	 (initial nao0))
      
      (output nai nao)
      )


   (component (type decaying-pool) (name k)

      (input (ik from ion-currents))

      (const  d       = .2)
      (const  ko0     = 5.)
      (const  ki0     = 140.)
      (const  beta    = 0.075)
      
      (d (ki) =  ((neg (ik) / (2 * F * d)) * 1e4 - (beta * (ki - ki0)))
	 (initial ki0))
      
      (d (ko) =  ((ik / (2 * F * d)) * 1e4 - (beta * (ko - ko0)))
	 (initial ko0))
      
      (output ki ko)
      )


   (input 
    (ki from ion-pools)
    (ko from ion-pools)
    (nai from ion-pools)
    (nao from ion-pools)
    )

   (ek  = ((1e3) * (R * (celsius + 273.15)) / (F) * ln (ko / ki)))
   (ena = ((1e3) * (R * (celsius + 273.15)) / (F) * ln (nao / nai)))

   (component (type ionic-current) (name CaHVA )
	      
      (input 
       (cai from ion-pools)
       (cao from ion-pools))
	      
      (component (type gate)

		 ;; rate constants
		 
		 (Q10 = (pow (3 ((celsius - 20) / 10))))
		 
		 (const Aalpha_s  = 0.04944)
		 (const Kalpha_s  =  15.87301587302)
		 (const V0alpha_s = -29.06)
		 
		 (const Abeta_s  = 0.08298)
		 (const Kbeta_s  =  -25.641)
		 (const V0beta_s = -18.66)
		 
		 (const Aalpha_u  = 0.0013)
		 (const Kalpha_u  =  -18.183)
		 (const V0alpha_u = -48)
		 
		 (const Abeta_u = 0.0013)
		 (const Kbeta_u = 83.33)
		 (const V0beta_u = -48)
		 
		 ;; rate functions
		 
		 (defun alpha_s (v Q10)
		   (Q10 * Aalpha_s * exp((v - V0alpha_s) / Kalpha_s)))
		 
		 (defun beta_s (v Q10)
		   (Q10 * Abeta_s * exp((v - V0beta_s) / Kbeta_s)))
		 
		 (defun alpha_u (v Q10)
		   (Q10 * Aalpha_u * exp((v - V0alpha_u) / Kalpha_u)))
		 
		 (defun beta_u (v Q10)
		   (Q10 * Abeta_u * exp((v - V0beta_u) / Kbeta_u)))

		 (s_inf = ((alpha_s (v Q10))/(alpha_s (v Q10) + beta_s (v Q10))))
		 (tau_s = (1 / (alpha_s (v Q10) + beta_s (v Q10)) ))

		 (u_inf = ((alpha_u (v Q10))/(alpha_u (v Q10) + beta_u (v Q10)) ))
		 (tau_u = (1 / (alpha_u (v Q10) + beta_u (v Q10)) ))

		 (hh-ionic-gate 
		  (CaHVA  ;; ion name: exported variables will be of the form {ion}_{id}
		   (initial-m  s_inf)
		   (initial-h  u_inf)
		   (m-power    2)
		   (h-power    1)
		   (m-inf      s_inf)
		   (m-tau      tau_s)
		   (h-inf      u_inf)
		   (h-tau      tau_s)
		   ))
		 
		 )
	      
	      (component (type pore)
			 (const  gbar  = 460e-6)
			 (output gbar ))
	      
	      (component (type permeating-ion) (name ca)
			 (e = ((1e3) * (R * (celsius + 273.15)) / (2 * F) * ln (cao / cai)))
			 (output e)
			 )
	      
	      ) ;; end CaHVA current


   (component (type voltage-clamp) (name CaHVA)
	      
	      (const vchold   = -71)
	      (const vcbase   = -69)
	      (const vcinc    = 10)
	      (const vcsteps  = 8)
	      (const vchdur   = 30)
	      (const vcbdur   = 100)
	      
	      (output vchold vcbase vcinc vcsteps vchdur vcbdur)
	      )

   
   (component (type ionic-current) (name CaLVA )
	      
      (input 
       (ca2i from ion-pools)
       (ca2o from ion-pools))

      (component (type gate)

		 (const shift   = 2) ; screening charge for Ca_o = 2 mM
		 
		 (const v0_m_inf = -50)
		 (const v0_h_inf = -78)
		 (const k_m_inf  = -7.4)
		 (const k_h_inf  = 5.0)
	
		 (const C_tau_m   = 3)
		 (const A_tau_m   = 1.0)
		 (const v0_tau_m1 = -25)
		 (const v0_tau_m2 = -100)
		 (const k_tau_m1  = 10)
		 (const k_tau_m2 = -15)
		 
		 (const C_tau_h   = 85)
		 (const A_tau_h   = 1.0)
		 (const v0_tau_h1 = -46)
		 (const v0_tau_h2 = -405)
		 (const k_tau_h1  = 4)
		 (const k_tau_h2  = -50)
		 
			 
		 ;; rate functions
		 
		 (phi_m = (pow (5.0 ((celsius - 24) / 10))))
		 (phi_h = (pow (3.0 ((celsius - 24) / 10))))
		 
		 (m_inf = (1.0 / ( 1 + exp ((v + shift - v0_m_inf) / k_m_inf)) ))
		 (h_inf = (1.0 / ( 1 + exp ((v + shift - v0_h_inf) / k_h_inf)) ))
		 
		 (tau_m = ( (C_tau_m + A_tau_m / ( exp ((v + shift - v0_tau_m1) / k_tau_m1) + 
						       exp ((v + shift - v0_tau_m2) / k_tau_m2) ) ) / phi_m) )
		 
		 (tau_h = ( (C_tau_h + A_tau_h / ( exp ((v + shift - v0_tau_h1 ) / k_tau_h1) + 
						       exp ((v + shift - v0_tau_h2) / k_tau_h2) ) ) / phi_h) )
		 

		 (hh-ionic-gate 
		  (CaLVA  ;; ion name: exported variables will be of the form {ion}_{id}
		   (initial-m  m_inf)
		   (initial-h  h_inf)
		   (m-power    2)
		   (h-power    1)
		   (m-inf      m_inf)
		   (m-tau      tau_m)
		   (h-inf      h_inf)
		   (h-tau      tau_h)
		   ))
		 )
      
      
      (component (type pore)
		 (const  gbar  = 2.5e-4)
		 (output gbar ))

	      
      (component (type permeating-ion) (name ca2)
                 (const valence = 2)
		 (e = ((1e3) * (R * (celsius + 273.15)) / (2 * F) * ln (ca2o / ca2i)))
		 (output e valence))

	      
      ) ;; end CaLVA current



   (component (type voltage-clamp) (name CaLVA)
	      
	      (const vchold   = -71)
	      (const vcbase   = -69)
	      (const vcinc    = 10)
	      (const vcsteps  = 8)
	      (const vchdur   = 200)
	      (const vcbdur   = 30)
	      
	      (output vchold vcbase vcinc vcsteps vchdur vcbdur)
	      )


      
   (component (type ionic-current) (name HCN1)

   	      (const Ehalf = -72.49)
   	      (const c = 0.11305)
	      
   	      (const rA = 0.002096)
   	      (const rB = 0.97596)
	      
   	      (defun r (potential)
   		((rA * potential) + rB))
	      
   	      (defun tau (potential t1 t2 t3)
   		(exp (((t1 * potential) - t2) * t3)))
	      
   	      (defun o_inf (potential Ehalf c)
   		(1 / (1 + exp ((potential - Ehalf) * c))))
              

   	      (component (type gate)

   			 ;; rate constants
	
                         (const tCs = 0.01451)
                         (const tDs = -4.056)
                         (const tEs = 2.302585092)

                         (o_slow_inf = ((1 - r (v)) * o_inf (v Ehalf c)))
			
                         (tau_s =  (tau (v tCs tDs tEs)) )

                         (d (o_slow) = ((o_slow_inf - o_slow) / tau_s) 
                            (initial o_slow_inf))
                         
                         (output o_slow)

   			 )
	      
   	      (component (type gate)
                         

   			 ;; rate constants
	
                         (const tCf = 0.01371)
                         (const tDf = -3.368)
                         (const tEf = 2.302585092)

                         (o_fast_inf = (r (v) * o_inf (v Ehalf c)))
			
                         (tau_f =  (tau (v tCf tDf tEf)) )

                         (d (o_fast) = ((o_fast_inf - o_fast) / tau_f) 
                            (initial o_fast_inf))
                         
                         (output o_fast)

   			 )
	      
   	      (component (type pore)
   			 (const  gbar  = 5e-5)
   			 (output gbar))
	      
   	      (component (type permeating-ion) (name non-specific)
   			 (const e = -20)
   			 (output e ))
	      
   	      ) ;; end HCN1 current


              
   (component (type voltage-clamp) (name HCN1)
	      
   	      (const vchold   = -71)
   	      (const vcbase   = -69)
   	      (const vcinc    = 10)
   	      (const vcsteps  = 8)
   	      (const vchdur   = 30)
   	      (const vcbdur   = 100)
	      
   	      (output vchold vcbase vcinc vcsteps vchdur vcbdur)
   	      )


      
   (component (type ionic-current) (name HCN2)
                         

   	      (const Ehalf = -81.95)
   	      (const c = 0.1661)
	      
   	      ;; rate constants

   	      (const rA = -0.0227)
   	      (const rB = -1.4694)

   	      (defun r (potential r1 r2)
   		(if (potential >= -64.70) 
   		    then  0.0
   		    else (if (potential <= -108.70) 
   			     then 1.0
   			     else (r1 * potential) + r2)))

   	      (defun o_inf (potential Ehalf c)
   		(1 / (1 + exp((potential - Ehalf) * c))))
              
   	      (component (type gate)
                         

   			 ;; rate constants

                         (const tCs = 0.0152)
                         (const tDs = -5.2944)
                         (const tEs = 2.3026)
                         
                         (defun tau_slow (potential t1 t2 t3)
                           (exp (t3 * ((t1 * potential) - t2))))

                         (o_slow_inf = ((1 - r (v rA rB)) * o_inf (v Ehalf c)))

                         (tau_s =  (tau_slow(v tCs tDs tEs)))

                         (d (o_slow) = ((o_slow_inf - o_slow) / tau_s) 
                            (initial o_slow_inf))

                         (output o_slow)

   			 )
	      
   	      (component (type gate)
                         

   			 ;; rate constants

                         (const tCf = 0.0269)
                         (const tDf = -5.6111)
                         (const tEf = 2.3026)
                         
                         (defun tau_fast (potential t1 t2 t3)
                           (exp (t3 * ((t1 * potential) - t2))))

                         (o_fast_inf = (r (v rA rB) * o_inf (v Ehalf c)))

                         (tau_f =  (tau_fast(v tCf tDf tEf)))

                         (d (o_fast) = ((o_fast_inf - o_fast) / tau_f) 
                            (initial o_fast_inf))

                         (output o_fast)

   			 )
	      
   	      (component (type pore)
   			 (const  gbar  = 8e-5)
   			 (output gbar))
	      
   	      (component (type permeating-ion) (name non-specific)
   			 (const e = -20)
   			 (output e ))
	      
   	      ) ;; end HCN2 current



   (component (type voltage-clamp) (name HCN2)
	      
   	      (const vchold   = -71)
   	      (const vcbase   = -69)
   	      (const vcinc    = 10)
   	      (const vcsteps  = 8)
   	      (const vchdur   = 30)
   	      (const vcbdur   = 100)
	      
   	      (output vchold vcbase vcinc vcsteps vchdur vcbdur)
   	      )

   

   (component (type ionic-current) (name KA )

	      (defun sigm (x y) (1 / (exp (x / y) + 1)))
	      
	      (component (type gate)
			 
			 ;; rate constants
			 
			 (Q10 = (pow (3 ((celsius - 25.5) / 10))))

			 (const Aalpha_a  = 0.8147)
			 (const Kalpha_a  = -23.32708)
			 (const V0alpha_a = -9.17203)
			 (const Abeta_a   = 0.1655)
			 (const Kbeta_a   = 19.47175)
			 (const V0beta_a  = -18.27914)

			 (const Aalpha_b  = 0.0368)
			 (const Kalpha_b  = 12.8433)
			 (const V0alpha_b = -111.33209)
			 (const Abeta_b   = 0.0345)
			 (const Kbeta_b   = -8.90123)
			 (const V0beta_b  = -49.9537)

			 (const V0_ainf = -38)
			 (const  K_ainf = -17)

			 (const V0_binf   = -78.8)
			 (const K_binf    = 8.4)

			 
			 ;; rate functions

			 (defun alpha_a (v Q10)
			   (Q10 * Aalpha_a * sigm((v - V0alpha_a) Kalpha_a)))

			 (defun beta_a (v Q10)
			   (Q10 * (Abeta_a / exp((v - V0beta_a) / Kbeta_a))))

			 (defun alpha_b (v Q10)
			   (Q10 * Aalpha_b * sigm((v - V0alpha_b) Kalpha_b)))

			 (defun beta_b (v Q10)
			   (Q10 * Abeta_b * sigm((v - V0beta_b) Kbeta_b)))



			 (a_inf = (1 / (1 + exp ((v - V0_ainf) / K_ainf)))) 
			 (tau_a = (1 / (alpha_a (v Q10) + beta_a (v Q10)) ))
			 (b_inf = (1 / (1 + exp ((v - V0_binf) / K_binf))))
			 (tau_b = (1 / (alpha_b (v Q10) + beta_b (v Q10)) ))


			 (hh-ionic-gate 
			  (KA  ;; ion name: exported variables will be of the form {ion}_{id}
			   (initial-m  (a_inf))
			   (initial-h  (b_inf))
			   (m-power    3)
			   (h-power    1)
			   (m-inf      a_inf)
			   (m-tau      tau_a)
			   (h-inf      b_inf)
			   (h-tau      tau_b)
			   ))

			 )

	      	      
	      (component (type pore)
			 (const  gbar  = 0.008)
			 (output gbar ))

	      
	      (component (type permeating-ion) (name k)
			 (e = ek)
			 (output e ))
	      
	      ) ;; end KA current
	      


   (component (type voltage-clamp) (name KA)
	      
	      (const vchold   = -71)
	      (const vcbase   = -69)
	      (const vcinc    = 10)
	      (const vcsteps  = 8)
	      (const vchdur   = 30)
	      (const vcbdur   = 100)
	      
	      (output vchold vcbase vcinc vcsteps vchdur vcbdur)
	      )

   

   (component (type ionic-current) (name KCa )

      (input
       (cai from ion-pools))
	      
      (component (type gate)

		 ;; rate constants
		 (Q10 = (pow (3 ((celsius - 30) / 10))))
		 
		 (const Aalpha_c = 7)
		 (const Balpha_c = 1.5e-3)
		 
		 (const Kalpha_c =  -11.765)
		 
		 (const Abeta_c = 1.)
		 (const Bbeta_c = 0.15e-3)

		 (const Kbeta_c = -11.765)
		 
		 ;; rate functions
		 (defun alpha_c (v cai Q10)
		   (Q10 * Aalpha_c / (1 + (Balpha_c * exp(v / Kalpha_c) / cai)))) 
		 
		 (defun beta_c (v cai Q10)
		   (Q10 * Abeta_c / (1 + (cai / (Bbeta_c * exp (v / Kbeta_c))) )))
             
                 (c_inf = ((alpha_c (v cai Q10)) / (alpha_c (v cai Q10) + beta_c (v cai Q10)) ))
                 (tau_c = (1 / (alpha_c (v cai Q10) + beta_c (v cai Q10)) ))

		 (hh-ionic-gate 
		  (KCa  ;; ion name: exported variables will be of the form {ion}_{id}
		   (initial-m  c_inf)
		   (m-power    1)
		   (h-power    0)
                   (m-inf      c_inf) 
                   (m-tau      tau_c)
		   ))
		 
		 )
      
      (component (type pore)
		 (const  gbar  = 0.003)
		 (output gbar ))
      
      
      (component (type permeating-ion) (name k)
		 (e = ek)
		 (output e ))
      
      (component (type modulating-ion) (name ca) )
      
      ) ;; end KCa current
   
   (component (type voltage-clamp) (name KCa)
	      
	      (const vchold   = -71)
	      (const vcbase   = -69)
	      (const vcinc    = 10)
	      (const vcsteps  = 8)
	      (const vchdur   = 30)
	      (const vcbdur   = 100)
	      
	      (output vchold vcbase vcinc vcsteps vchdur vcbdur)
	      )


   (component (type ionic-current) (name KM )
	      
	      (component (type gate)

			 ;; rate constants
			 (const Aalpha_n = 0.0033)

			 (const Kalpha_n  = 40)
			 (const V0alpha_n = -30)
			 (const Abeta_n   = 0.0033)

			 (const Kbeta_n  = -20)
			 (const V0beta_n = -30)
			 (const V0_ninf  = -35)
			 (const   B_ninf = 6)
			 
			 (Q10 = (pow (3 ((celsius - 22) / 10))))
			 
			 ;; rate equations
			 (defun alpha_n (v Q10)
			   (Q10 * Aalpha_n * exp((v - V0alpha_n) / Kalpha_n) ))

			 (defun beta_n (v Q10)
			   (Q10 * Abeta_n * exp((v - V0beta_n) / Kbeta_n) ))

			 (hh-ionic-gate 
			  (KM  ;; ion name: exported variables will be of the form {ion}_{id}
			   (initial-m  ((1 / (1 + exp((neg (v - V0_ninf)) / B_ninf)))))
			   (m-power    1)
			   (h-power    0)
			   (m-tau      ((1 / (alpha_n(v Q10) + beta_n (v Q10)) )))
			   (m-inf      ((1 / (1 + exp((neg (v - V0_ninf)) / B_ninf)))))
			   ))
			 )
	      
	      (component (type pore)
			 (const  gbar  = 0.001)
			 (output gbar ))
	      
	      (component (type permeating-ion) (name k)
			 (const e = -84.69)
			 (output e ))
	      
	      ) ;; end KM current



   (component (type voltage-clamp) (name KM)
	      
	      (const vchold   = -71)
	      (const vcbase   = -69)
	      (const vcinc    = 10)
	      (const vcsteps  = 8)
	      (const vchdur   = 30)
	      (const vcbdur   = 100)
	      
	      (output vchold vcbase vcinc vcsteps vchdur vcbdur)
	      )

   

   (component (type ionic-current) (name KV )
	      
	      (defun linoid (x y) 
		(if ((abs (x / y)) < 1e-6) 
		    then (y * (1 - ((x / y) / 2)))
		    else (x / (exp (x / y) - 1))
		    ))


	      (component (type gate)

			 ;; rate constants

			 (const Aalpha_n = -0.01)
			 (const Kalpha_n = -10)
			 (const V0alpha_n = -26)
			 (const Abeta_n = 0.125)
	
			 (const Kbeta_n = -80)
			 (const V0beta_n = -36)

			 ;; rate functions
			 (Q10 = (pow (3 ((celsius - 6.3) / 10))))

			 (defun alpha_n (v Q10) 
			   (Q10 * Aalpha_n * linoid ((v - V0alpha_n) Kalpha_n)))

			 (defun beta_n (v Q10) 
			   (Q10 * Abeta_n * exp((v - V0beta_n) / Kbeta_n) ))

                         (n_inf = ((alpha_n (v Q10)) / (alpha_n (v Q10) + beta_n (v Q10)) ))
                         (tau_n = (1 / (alpha_n (v Q10) + beta_n (v Q10)) ))

			 (hh-ionic-gate 
			  (KV  ;; ion name: exported variables will be of the form {ion}_{id}
			   (initial-m  n_inf)
			   (m-power    4)
			   (h-power    0)
			   (m-inf     (n_inf))
			   (m-tau     (tau_n))
			   ))
			 )

	      (component (type pore)
			 (const  gbar  = 0.032)
			 (output gbar ))
	      
	      (component (type permeating-ion) (name k)
			 (e = ek)
			 (output e ))
	      
	      ) ;; end KV current
	      

   (component (type voltage-clamp) (name KV)
	      
	      (const vchold   = -71)
	      (const vcbase   = -69)
	      (const vcinc    = 10)
	      (const vcsteps  = 8)
	      (const vchdur   = 30)
	      (const vcbdur   = 100)
	      
	      (output vchold vcbase vcinc vcsteps vchdur vcbdur)
	      )



   
   (component (type ionic-current) (name SK2 )

      (input
       (cai from ion-pools))
	      
      (component (type gate)

		 (Q10 = (pow (3 ((celsius - 23) / 10))))
		 
		 (const diff = 3) ;; Diffusion factor
		 
		 ;; rates ca-independent
		 (const invc1 = 80e-3)
		 (const invc2 = 80e-3)
		 (const invc3 = 200e-3)

		 (const invo1 = 1)
		 (const invo2 = 100e-3)
		 (const diro1 = 160e-3)
		 (const diro2 = 1.2)

		 ;; rates ca-dependent
		 (const dirc2 = 200)
		 (const dirc3 = 160)
		 (const dirc4 = 80)

		 (invc1_t = (invc1 * Q10  ))
		 (invc2_t = (invc2 * Q10 ))
		 (invc3_t = (invc3 * Q10 ))
		 (invo1_t = (invo1 * Q10 ))
		 (invo2_t = (invo2 * Q10 ))
		 (diro1_t = (diro1 * Q10 ))
		 (diro2_t = (diro2 * Q10 ))
		 (dirc2_t = (dirc2 * Q10 ))
		 (dirc3_t = (dirc3 * Q10 ))
		 (dirc4_t = (dirc4 * Q10 ))


		 (dirc2_t_ca = (dirc2_t * (cai / diff) ))
		 (dirc3_t_ca = (dirc3_t * (cai / diff) ))
		 (dirc4_t_ca = (dirc4_t * (cai / diff) ))

		 
		 (reaction
		  (SK2_z
		   (transitions 
		    (<-> c1 c2 dirc2_t_ca invc1_t)
		    (<-> c2 c3 dirc3_t_ca invc2_t) 
		    (<-> c3 c4 dirc4_t_ca invc3_t) 
		    (<-> c3 o1 diro1_t invo1_t) 
		    (<-> c4 o2 diro2_t invo2_t) 
		    )
		   (conserve  ((1 = (c1 + c2 + c3 + c4 + o2 + o1))))
		   (open o1 o2) 
		   (power 1)))
		 
		 (output SK2_z)
		 
		 )

      (component (type pore)
		 (const  gbar  = 0.038)
		 (output gbar ))
      
      
      (component (type permeating-ion) (name k)
		 (e = ek)
		 (output e ))

      (component (type modulating-ion) (name ca) )
      
      ) ;; end SK2 current



   (component (type voltage-clamp) (name SK2)
           
   	      (const vchold   = -71)
   	      (const vcbase   = -69)
   	      (const vcinc    = 10)
   	      (const vcsteps  = 8)
   	      (const vchdur   = 30)
   	      (const vcbdur   = 100)
	      
   	      (output vchold vcbase vcinc vcsteps vchdur vcbdur)
   	      )
   
   (component (type ionic-current) (name Na )
	      
	      
	      (defun linoid (x y) 
		(if ((abs (x / y)) < 1e-6) 
		    then (y * (1 - ((x / y) / 2)))
		    else (x / (1 - exp (x / y) ))
		    ))
	      
	      
	      (component (type gate)
	      
	      ;; rate constants
   			 
			 (Q10 = (pow (3 ((celsius - 20) / 10))))

   			 (const Aalpha_u  = 0.3)
   			 (const Kalpha_u  = -10)
   			 (const V0alpha_u = -25)
	
   			 (const Abeta_u  = 12)
   			 (const Kbeta_u  = -18.182)
   			 (const V0beta_u = -50)

   			 (const Aalpha_v  = 0.21)
   			 (const Kalpha_v  = -3.333)
   			 (const V0alpha_v = -50)
 
   			 (const Abeta_v  = 3)
   			 (const Kbeta_v  = -5)
   			 (const V0beta_v = -17)

   			 ;; rate functions
   			 (defun alpha_u (v Q10)	
   			   (Q10 * Aalpha_u * linoid((v - V0alpha_u) Kalpha_u) ))

   			 (defun beta_u (v Q10)
   			   (Q10 * Abeta_u * exp((v - V0beta_u) / Kbeta_u) ))

   			 (defun alpha_v (v Q10)
   			   (Q10 * Aalpha_v * exp((v - V0alpha_v) / Kalpha_v) ))	
				
   			 (defun beta_v (v Q10)
   			   (Q10 * Abeta_v / (1 + exp((v - V0beta_v) / Kbeta_v) )))

			 (u_inf = ((alpha_u (v Q10)) / (alpha_u (v Q10) + beta_u (v Q10)) ))
			 (tau_u = (1 / (alpha_u (v Q10) + beta_u (v Q10))))

			 (v_inf = ((alpha_v (v Q10)) / (alpha_v (v Q10) + beta_v (v Q10)) ))
			 (tau_v = (1 / (alpha_v (v Q10) + beta_v (v Q10)) ))
			 
   			 (hh-ionic-gate 
   			  (Na  ;; ion name: exported variables will be of the form {ion}_{id}
   			   (initial-m  (u_inf))
   			   (initial-h  (v_inf))
   			   (m-power    3)
   			   (h-power    1)
  			   (m-inf     (u_inf))
   			   (m-tau     (tau_u))
   			   (h-inf     (v_inf))
   			   (h-tau     (tau_v))
   			   ))
			 
   			 )
	      
   	      (component (type pore)
   			 (const  gbar  = 0.048)
   			 (output gbar ))

	      
   	      (component (type permeating-ion) (name na)
   			 (e = ena)
   			 (output e ))
	      
   	      ) ;; end Na current


   (component (type voltage-clamp) (name Na)

   	      (const vchold   = -71)
   	      (const vcbase   = -60)
   	      (const vcinc    = 10)
   	      (const vcsteps  = 9)
   	      (const vchdur   = 30)
   	      (const vcbdur   = 100)
           
   	      (output vchold vcbase vcinc vcsteps vchdur vcbdur))

   
   (component (type ionic-current) (name NaP )
	      
   	      (defun linoid (x y) 
   		(if ((abs (x / y)) < 1e-6) 
   		    then (y * (1 - ((x / y) / 2)))
   		    else (x / (exp (x / y) - 1))
   		    ))


   	      (component (type gate)

   			 ;; rate constants
   			 ( Q10 = (pow (3 ((celsius - 30) / 10))))

                         (const Aalpha_m  = -0.91)
                         (const Kalpha_m  = -5)
                         (const V0alpha_m = -40)
                         (const Abeta_m	  = 0.62)
                         (const Kbeta_m   = 5)
                         (const V0beta_m  = -40)
                         (const V0_minf   = -43)
                         (const B_minf    = 5)

   			 ;; rate functions

   			 (defun alpha_m (v Q10) 
   			   (Q10 * Aalpha_m * linoid( ( v - V0alpha_m ) Kalpha_m) ))

   			 (defun beta_m (v Q10) 
   			   (Q10 * Abeta_m * linoid( ( v - V0beta_m )  Kbeta_m ) ))

   			 (hh-ionic-gate 
   			  (NaP  ;; ion name: exported variables will be of the form {ion}_{id}
   			   (initial-m  ((1 / (1 + exp ((neg (v - V0_minf)) / B_minf)))))
   			   (m-power    1)
   			   (h-power    0)
   			   (m-inf     ((1 / (1 + exp ((neg (v - V0_minf)) / B_minf)))))
   			   (m-tau     ((5 / (alpha_m (v Q10) + beta_m (v Q10)) )))
   			   ))
   			 )

   	      (component (type pore)
   			 (const  gbar  = 0.00019)
   			 (output gbar ))

   	      (component (type permeating-ion) (name na)
   			 (e = ena)
   			 (output e ))
	      
   	      ) ;; end NaP current


   (component (type voltage-clamp) (name NaP)

   	      (const vchold   = -71)
   	      (const vcbase   = -60)
   	      (const vcinc    = 10)
   	      (const vcsteps  = 9)
   	      (const vchdur   = 30)
   	      (const vcbdur   = 100)
           
   	      (output vchold vcbase vcinc vcsteps vchdur vcbdur))

   
   (component (type ionic-current) (name NaR )
	      
   	      (component (type gate)

   			 ;; rate constants
   			 (Q10 = (pow (3 ((celsius - 20) / 10))))

   			 (const Aalpha_s     = -0.00493)
   			 (const V0alpha_s    = -4.48754)
   			 (const Kalpha_s     = -6.81881)
   			 (const Shiftalpha_s = 0.00008)

   			 (const Abeta_s     = 0.01558)
   			 (const V0beta_s    = 43.97494)
   			 (const Kbeta_s     =  0.10818)
   			 (const Shiftbeta_s = 0.04752)

   			 (const Aalpha_f  = 0.31836)
   			 (const V0alpha_f = -80)
   			 (const Kalpha_f  = -62.52621)

   			 (const Abeta_f  = 0.01014)
   			 (const V0beta_f = -83.3332)
   			 (const Kbeta_f  = 16.05379)

   			 ;; rate functions
   			 (defun alpha_s (v Q10) 
   			   (Q10 * (Shiftalpha_s + ((Aalpha_s * ((v + V0alpha_s) )) / (exp ((v + V0alpha_s) / Kalpha_s) - 1)))))

   			 (defun beta_s (v Q10) 
                           (let ((x1 ((v + V0beta_s) / Kbeta_s)))
   			     (Q10 * (Shiftbeta_s + Abeta_s * ((v + V0beta_s) / (exp((if (x1 > 200) then 200 else x1)) - 1))))))

   			 (defun alpha_f (v Q10) 
   			   (Q10 * Aalpha_f * exp( ( v - V0alpha_f ) / Kalpha_f)))

   			 (defun beta_f (v Q10) 
   			   (Q10 * Abeta_f * exp( ( v - V0beta_f ) / Kbeta_f )  ))

			 (s_inf = ((alpha_s (v Q10)) / (alpha_s (v Q10) + beta_s (v Q10)) ))
			 (tau_s = (1 / (alpha_s (v Q10) + beta_s (v Q10)) ))
			 (f_inf = ((alpha_f (v Q10)) / (alpha_f (v Q10) + beta_f (v Q10)) ))
			 (tau_f = (1 / (alpha_f (v Q10) + beta_f (v Q10)) ))

   			 (hh-ionic-gate 
   			  (NaR  ;; ion name: exported variables will be of the form {ion}_{id}
   			   (initial-m  (s_inf))
   			   (initial-h  (f_inf))
   			   (m-power    1)
   			   (h-power    1)
   			   (m-inf     (s_inf))
   			   (m-tau     (tau_s))
   			   (h-inf     (f_inf))
   			   (h-tau     (tau_f))

   			   ))
   			 )

   	      (component (type pore)
   			 (const  gbar  = 0.0017)
   			 (output gbar ))

   	      (component (type permeating-ion) (name na)
   			 (e = ena)
   			 (output e ))
	      
   	      ) ;; end Nar current


   (component (type voltage-clamp) (name NaR)

   	      (const vchold   = -71)
   	      (const vcbase   = -60)
   	      (const vcinc    = 10)
   	      (const vcsteps  = 9)
   	      (const vchdur   = 30)
   	      (const vcbdur   = 100)
           
   	      (output vchold vcbase vcinc vcsteps vchdur vcbdur))

      
   (component (type ionic-current) (name Lkg)
	      
	      (component (type pore)
			 (const  gbar  = (21e-6))
			 (output gbar))
	      
	      (component (type permeating-ion) (name non-specific)
			 (const e = -55)
			 (output e ))
	      
	      ) ;; end leak current
   )

   ;; Following are templates for various driver scripts used to run this model
   (
    ("template.hoc" ()  
#<<EOF
/*******Cerebellar Golgi Cell Model **********

Developers:    Sergio Solinas & Egidio D'Angelo
Code contributors:  Thierry Neius, Shyam Diwakar, Lia Forti
Data Analysis: Sergio Solinas

Work Progress: April 2004 - May 2007

Developed At:  Università Degli Studi Di Pavia
	       Dipartimento Di Scienze Fisiologiche
	       Pavia - Italia
	       
Model Published in: 
             Sergio M. Solinas, Lia Forti, Elisabetta Cesana, 
             Jonathan Mapelli, Erik De Schutter and Egidio D`Angelo (2008)
             Computational reconstruction of pacemaking and intrinsic 
             electroresponsiveness in cerebellar golgi cells
             Frontiers in Cellular Neuroscience 2:2


********************************************/

// In this configuration the ion channels 
// were not corrected for the Liquid Junction potential.
// The ion reversal potential were corrected in agreement
// with the voltage shift.
// See Table 1 Solinas et al. 2008 Frontiers Neurosci 2:2

begintemplate GoC
public soma,elec,seal,dend
public SpikeTrain, RT_Vm, EL_Vm

create soma
create dend[3]

objref SpikeTrain, netcon, nil
objref RT_Vm, EL_Vm

proc init() {

    RT_Vm = new Vector()
    EL_Vm = new Vector()
    create soma
    soma {
	nseg = 1
	diam = 27 // 22 pF Dieudonne98
	L = 27
	Ra = 100 // From Roth&Hausser2000
	celsius = 23
	
	insert Golgi_Lkg
	
	insert Golgi_Na
	insert Golgi_NaR
	insert Golgi_NaP
	
	insert Golgi_CaHVA
	insert Golgi_CaLVA
		
	insert Golgi_KV
	insert Golgi_KM
	insert Golgi_KA

	insert Golgi_KCa
	insert Golgi_SK2
 	
        insert Golgi_HCN1
        insert Golgi_HCN2

	insert Golgi_ca
	insert Golgi_ca2
	insert Golgi_na
	insert Golgi_k
	
	cai0_ca_ion = 50e-6
	ca2i0_ca2_ion = cai0_ca_ion
	
	cai0_Golgi_Ca = cai0_ca_ion
	ca2i0_Golgi_Ca2 = cai0_ca_ion
	
	cai = cai0_ca_ion
	ca2i = cai
	ca2o = cao

	nai0_na_ion = 5
	nai = nai0_na_ion
	ki0_k_ion = 140
	ki = ki0_k_ion
 
	SpikeTrain = new Vector()
	netcon = new NetCon(&v(0.5),nil)
	netcon.threshold=-20
	netcon.record(SpikeTrain)
	
	RT_Vm.record(&v(0.5))
    }
    
    create dend[3]
    for i=0,2 {
	dend[i] {
	    nseg = 10
	    diam = 3
	    L = 113
	    Ra = 100
	    celsius = 23
	    
	    insert Golgi_Lkg
	}
	connect dend[i](0), soma(1)	
    }
    

}

		    
endtemplate GoC
EOF
)
    ("reduced_template.hoc" ()  
#<<EOF
/*******Cerebellar Golgi Cell Model **********

Reduced single-compartment cerebellar Golgi cell model

Developers:    Sergio Solinas & Egidio D'Angelo
Code contributors:  Thierry Neius, Shyam Diwakar, Lia Forti
Data Analysis: Sergio Solinas

Work Progress: April 2004 - May 2007

Developed At:  Università Degli Studi Di Pavia
	       Dipartimento Di Scienze Fisiologiche
	       Pavia - Italia
	       
Model Published in: 
             Sergio M. Solinas, Lia Forti, Elisabetta Cesana, 
             Jonathan Mapelli, Erik De Schutter and Egidio D`Angelo (2008)
             Computational reconstruction of pacemaking and intrinsic 
             electroresponsiveness in cerebellar golgi cells
             Frontiers in Cellular Neuroscience 2:2


********************************************/

// In this configuration the ion channels 
// were not corrected for the Liquid Junction potential.
// The ion reversal potential were corrected in agreement
// with the voltage shift.
// See Table 1 Solinas et al. 2008 Frontiers Neurosci 2:2

begintemplate GoC
public soma,axon,elec,seal,dend
public SpikeTrain, RT_Vm, EL_Vm

create soma

objref SpikeTrain, netcon, nil
objref RT_Vm, EL_Vm

proc init() {

    RT_Vm = new Vector()
    EL_Vm = new Vector()
    create soma
    soma {
	nseg = 1
	diam = 27 // 22 pF Dieudonne98
	L = 27
	Ra = 100 // From Roth&Hausser2000
	celsius = 23
	
	insert Golgi_Lkg
	
	insert Golgi_Na
	insert Golgi_NaR
	insert Golgi_NaP
	
	insert Golgi_CaHVA
	insert Golgi_CaLVA
		
	insert Golgi_KV
	insert Golgi_KM
	insert Golgi_KA

	insert Golgi_KCa
	insert Golgi_SK2
 	
        insert Golgi_HCN1
        insert Golgi_HCN2

	insert Golgi_ca
	insert Golgi_ca2
	
	cai0_ca_ion = 50e-6
	ca2i0_ca2_ion = cai0_ca_ion
	
	cai0_Golgi_Ca = cai0_ca_ion
	ca2i0_Golgi_Ca2 = cai0_ca_ion
	
	cai = cai0_ca_ion
	ca2i = cai
	ca2o = cao
	
	ena =  87.39
	ek  = -84.69

	SpikeTrain = new Vector()
	netcon = new NetCon(&v(0.5),nil)
	netcon.threshold=-20
	netcon.record(SpikeTrain)
	
	RT_Vm.record(&v(0.5))
    }
}

		    
endtemplate GoC
EOF
)

    ("protocol.hoc" ()  
#<<EOF
load_file("nrngui.hoc")
load_file("Golgi_protocol.ses")

// Load the Golgi cell template
xopen("Golgi_template.hoc")
objref goc
goc = new GoC()


prelength = 1000
mainlength = 2000


//**********************************************************************
proc simulate() { local preDT, mainDT, logsize  localobj logfile, tlog, Vlog, iklog, inalog, icalog, ica2log
    
    mainDT = 0.025
    preDT = 0.025
    
    dt = preDT
    tstop = prelength
    run()
    
    
    if ( stoprun == 1) return
    
    dt = mainDT
    continuerun(prelength + mainlength)
    if ( stoprun == 1) return
    
    logfile=$o1
    tlog=$o2
    Vlog=$o3
    iklog=$o4
    inalog=$o5
    icalog=$o6
    ica2log=$o7
    
    logsize = tlog.size()
    
    for i=0,tlog.size()-1 {
	logfile.printf("%g %g %g %g %g\n", tlog.x[i], Vlog.x[i], iklog.x[i], inalog.x[i], icalog.x[i], ica2log.x[i])
    }

}


//*************User-Interface*******************************************

nrnsecmenu(0.5, 1)

xpanel("Spontaneous firing")
xvalue("Time for Initialization", "prelength")
xvalue("Main duration", "mainlength")

xvalue("dt", "dt")
xvalue("t", "t")
xlabel("")
xbutton("Start", "simulate()")
xbutton("Stop", "stoprun = 1")
xpanel()

vec_sizes = (prelength+mainlength)/dt + 1	// recorded traces are all this size


objref  iklog
iklog = new Vector(vec_sizes)
iklog.record (&goc.soma.ik(0.5))

objref  inalog
inalog = new Vector(vec_sizes)
inalog.record (&goc.soma.ina(0.5))

objref  icalog
icalog = new Vector(vec_sizes)
icalog.record (&goc.soma.ica(0.5))

objref  ica2log
ica2log = new Vector(vec_sizes)
ica2log.record (&goc.soma.ica2(0.5))

objref  Vlog
Vlog = new Vector(vec_sizes)
Vlog.record (&goc.soma.v(0.5))

objref tlog
tlog = new Vector(vec_sizes,0)
tlog.record (&t)

objref logfile
logfile = new File()
logfile.wopen ( "Golgi_protocol.dat" )

simulate(logfile,tlog,Vlog,iklog,inalog,icalog,ica2log)
logfile.close()


quit()
EOF
)

    ("reduced_protocol.hoc" ()  
#<<EOF
load_file("nrngui.hoc")
load_file("Golgi_protocol.ses")

// Load the Golgi cell template
xopen("Golgi_reduced_template.hoc")
objref goc
goc = new GoC()


prelength = 1000
mainlength = 2000


//**********************************************************************
proc simulate() { local preDT, mainDT, logsize  localobj logfile, tlog, Vlog, iklog, inalog, icalog, ica2log
    
    mainDT = 0.025
    preDT = 0.025
    
    dt = preDT
    tstop = prelength
    run()
    
    
    if ( stoprun == 1) return
    
    dt = mainDT
    continuerun(prelength + mainlength)
    if ( stoprun == 1) return
    
    logfile=$o1
    tlog=$o2
    Vlog=$o3
    iklog=$o4
    inalog=$o5
    icalog=$o6
    ica2log=$o7
    
    logsize = tlog.size()
    
    for i=0,tlog.size()-1 {
	logfile.printf("%g %g %g %g %g\n", tlog.x[i], Vlog.x[i], iklog.x[i], inalog.x[i], icalog.x[i], ica2log.x[i])
    }

}


//*************User-Interface*******************************************

nrnsecmenu(0.5, 1)

xpanel("Spontaneous firing")
xvalue("Time for Initialization", "prelength")
xvalue("Main duration", "mainlength")

xvalue("dt", "dt")
xvalue("t", "t")
xlabel("")
xbutton("Start", "simulate()")
xbutton("Stop", "stoprun = 1")
xpanel()

vec_sizes = (prelength+mainlength)/dt + 1	// recorded traces are all this size


objref  iklog
iklog = new Vector(vec_sizes)
iklog.record (&goc.soma.ik(0.5))

objref  inalog
inalog = new Vector(vec_sizes)
inalog.record (&goc.soma.ina(0.5))

objref  icalog
icalog = new Vector(vec_sizes)
icalog.record (&goc.soma.ica(0.5))

objref  ica2log
ica2log = new Vector(vec_sizes)
ica2log.record (&goc.soma.ica2(0.5))

objref  Vlog
Vlog = new Vector(vec_sizes)
Vlog.record (&goc.soma.v(0.5))

objref tlog
tlog = new Vector(vec_sizes,0)
tlog.record (&t)

objref logfile
logfile = new File()
logfile.wopen ( "Golgi_reduced_protocol.dat" )

simulate(logfile,tlog,Vlog,iklog,inalog,icalog,ica2log)
logfile.close()


quit()
EOF
)
    ("protocol.ses" ()  
#<<EOF
{load_file("nrngui.hoc")}
objectvar save_window_, rvp_
objectvar scene_vector_[4]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}
{pwman_place(0,0,0)}
{
save_window_ = new Graph(0)
save_window_.size(0,5500,-80,50)
scene_vector_[2] = save_window_
{save_window_.view(0, -80, 5500, 130, 477, 9, 774.9, 232.3)}
graphList[0].append(save_window_)
save_window_.save_name("graphList[0].")
save_window_.addexpr("v(.5)", 1, 1, 0.8, 0.9, 2)
}
{doNotify()}
EOF
)

    (".hoc" ()  
#<<EOF

create soma
access soma

insert {{model_name}}

soma {
        nseg = 1 

{% with diam = default(diam, 9.76), L = default(L, 9.76) %}
        diam = {{diam}}
        L = {{L}} 
{% endwith %}

        cm = 1

        Ra = 100
    }
EOF
)

    ("plot_neuron_original_iclamp.m" ()  
#<<EOF

CaHVA0       = load ("original/CaHVA.dat");
CaHVA1       = load ("nemo_nmodl_generated/CaHVA.dat");

CaLVA0       = load ("original/CaLVA.dat");
CaLVA1       = load ("nemo_nmodl_generated/CaLVA.dat");

HCN10       = load ("original/HCN1.dat");
HCN11       = load ("nemo_nmodl_generated/HCN1.dat");

HCN20       = load ("original/HCN2.dat");
HCN21       = load ("nemo_nmodl_generated/HCN2.dat");

KA0       = load ("original/KA.dat");
KA1       = load ("nemo_nmodl_generated/KA.dat");

KCa0       = load ("original/KCa.dat");
KCa1       = load ("nemo_nmodl_generated/KCa.dat");

KM0      = load ("original/KM.dat");
KM1      = load ("nemo_nmodl_generated/KM.dat");

KV0      = load ("original/KV.dat");
KV1      = load ("nemo_nmodl_generated/KV.dat");

SK20      = load ("original/SK2.dat");
SK21      = load ("nemo_nmodl_generated/SK2.dat");

Na0      = load ("original/Na.dat");
Na1      = load ("nemo_nmodl_generated/Na.dat");

NaR0      = load ("original/NaR.dat");
NaR1      = load ("nemo_nmodl_generated/NaR.dat");

NaP0      = load ("original/NaP.dat");
NaP1      = load ("nemo_nmodl_generated/NaP.dat");


subplot(3,4,1);
plot(CaHVA0(:,1),CaHVA0(:,2),CaHVA1(:,1),CaHVA1(:,2),'linewidth',2);
title ("CaHVA current");

subplot(3,4,2);
plot(CaLVA0(:,1),CaLVA0(:,2),CaLVA1(:,1),CaLVA1(:,2),'linewidth',2);
title ("CaLVA current");

subplot(3,4,3);
plot(HCN10(:,1),HCN10(:,2),HCN11(:,1),HCN11(:,2),'linewidth',2);
title ("HCN1 current");

subplot(3,4,4);
plot(HCN20(:,1),HCN20(:,2),HCN21(:,1),HCN21(:,2),'linewidth',2);
title ("HCN2 current");

subplot(3,4,5);
plot(KA0(:,1),KA0(:,2),KA1(:,1),KA1(:,2),'linewidth',2);
title ("KA current");

subplot(3,4,6);
plot(KCa0(:,1),KCa0(:,2),KCa1(:,1),KCa1(:,2),'linewidth',2);
title ("KCa current");

subplot(3,4,7);
plot(KM0(:,1),KM0(:,2),KM1(:,1),KM1(:,2),'linewidth',2);
title ("KM current");

subplot(3,4,8);
plot(KV0(:,1),KV0(:,2),KV1(:,1),KV1(:,2),'linewidth',2);
title ("KV current");

subplot(3,4,9);
plot(SK20(:,1),SK20(:,2),SK21(:,1),SK21(:,2),'linewidth',2);
title ("SK2 current");

subplot(3,4,10);
plot(Na0(:,1),Na0(:,2),Na1(:,1),Na1(:,2),'linewidth',2);
title ("Na current");

subplot(3,4,11);
plot(NaR0(:,1),NaR0(:,2),NaR1(:,1),NaR1(:,2),'linewidth',2);
title ("NaR current");

subplot(3,4,12);
plot(NaP0(:,1),NaP0(:,2),NaP1(:,1),NaP1(:,2),'linewidth',2);
title ("NaP current");

print  ("NEURON_Original_Iclamp.eps", "-depsc");
EOF
)



    ("plot_neuron_original_vclamp.m" ()  
#<<EOF

CaHVA0       = load ("original/CaHVA.dat");
CaHVA1       = load ("nemo_nmodl_generated/CaHVA.dat");

CaLVA0       = load ("original/CaLVA.dat");
CaLVA1       = load ("nemo_nmodl_generated/CaLVA.dat");

HCN10       = load ("original/HCN1.dat");
HCN11       = load ("nemo_nmodl_generated/HCN1.dat");

HCN20       = load ("original/HCN2.dat");
HCN21       = load ("nemo_nmodl_generated/HCN2.dat");

KA0       = load ("original/KA.dat");
KA1       = load ("nemo_nmodl_generated/KA.dat");

KCa0       = load ("original/KCa.dat");
KCa1       = load ("nemo_nmodl_generated/KCa.dat");

KM0      = load ("original/KM.dat");
KM1      = load ("nemo_nmodl_generated/KM.dat");

KV0      = load ("original/KV.dat");
KV1      = load ("nemo_nmodl_generated/KV.dat");

SK20      = load ("original/SK2.dat");
SK21      = load ("nemo_nmodl_generated/SK2.dat");

Na0      = load ("original/Na.dat");
Na1      = load ("nemo_nmodl_generated/Na.dat");

NaR0      = load ("original/NaR.dat");
NaR1      = load ("nemo_nmodl_generated/NaR.dat");

NaP0      = load ("original/NaP.dat");
NaP1      = load ("nemo_nmodl_generated/NaP.dat");


subplot(3,4,1);
plot(CaHVA0(:,1),CaHVA0(:,2),CaHVA1(:,1),CaHVA1(:,2),'linewidth',2);
title ("CaHVA current");

subplot(3,4,2);
plot(CaLVA0(:,1),CaLVA0(:,2),CaLVA1(:,1),CaLVA1(:,2),'linewidth',2);
title ("CaLVA current");

subplot(3,4,3);
plot(HCN10(:,1),HCN10(:,2),HCN11(:,1),HCN11(:,2),'linewidth',2);
title ("HCN1 current");

subplot(3,4,4);
plot(HCN20(:,1),HCN20(:,2),HCN21(:,1),HCN21(:,2),'linewidth',2);
title ("HCN2 current");

subplot(3,4,5);
plot(KA0(:,1),KA0(:,2),KA1(:,1),KA1(:,2),'linewidth',2);
title ("KA current");

subplot(3,4,6);
plot(KCa0(:,1),KCa0(:,2),KCa1(:,1),KCa1(:,2),'linewidth',2);
title ("KCa current");

subplot(3,4,7);
plot(KM0(:,1),KM0(:,2),KM1(:,1),KM1(:,2),'linewidth',2);
title ("KM current");

subplot(3,4,8);
plot(KV0(:,1),KV0(:,2),KV1(:,1),KV1(:,2),'linewidth',2);
title ("KV current");

subplot(3,4,9);
plot(SK20(:,1),SK20(:,2),SK21(:,1),SK21(:,2),'linewidth',2);
title ("SK2 current");

subplot(3,4,10);
plot(Na0(:,1),Na0(:,2),Na1(:,1),Na1(:,2),'linewidth',2);
title ("Na current");

subplot(3,4,11);
plot(NaR0(:,1),NaR0(:,2),NaR1(:,1),NaR1(:,2),'linewidth',2);
title ("NaR current");

subplot(3,4,12);
plot(NaP0(:,1),NaP0(:,2),NaP1(:,1),NaP1(:,2),'linewidth',2);
title ("NaP current");

print  ("NEURON_Original_Vclamp.eps", "-depsc");

EOF
)

    ("nestmodule_bootstrap.sh" ()  
#<<EOF
#!/bin/sh

echo "Bootstrapping Golgi module..."

if test -d autom4te.cache ; then
# we must remove this cache, because it
# may screw up things if configure is run for
# different platforms. 
  echo "  -> Removing old automake cache ..."
  rm -rf autom4te.cache
fi

echo "  -> Running aclocal ..."
aclocal

echo "  -> Running libtoolize ..."
if [ `uname -s` = Darwin ] ; then
# libtoolize is glibtoolize on OSX
  LIBTOOLIZE=glibtoolize
else  
  LIBTOOLIZE=libtoolize
fi

libtool_major=`$LIBTOOLIZE --version | head -n1 | cut -d\) -f2 | cut -d\. -f1`
$LIBTOOLIZE --force --copy --ltdl

echo "  -> Re-running aclocal ..."
if test $libtool_major -le 2; then
  aclocal --force
else
  aclocal --force -I $(pwd)/libltdl/m4
fi

echo "  -> Running autoconf ..."
autoconf

# autoheader must run before automake 
echo "  -> Running autoheader ..."
autoheader

echo "  -> Running automake ..."
automake --foreign --add-missing --force-missing --copy

echo "Done."

EOF
)

    ("nestmodule_configure.ac" ()  
#<<EOF
AC_PREREQ(2.52)

AC_INIT(golgimodule, 1.0, raikov@oist.jp)

# These variables are exported to include/config.h
GOLGIMODULE_MAJOR=1
GOLGIMODULE_MINOR=0
GOLGIMODULE_PATCHLEVEL=0

# Exporting source and build directories requires full path names.
# Thus we have to expand.
# Here, we are in top build dir, since source dir must exist, we can just
# move there and call pwd
if test "x$srcdir" = x ; then
  PKGSRCDIR=`pwd`
else
  PKGSRCDIR=`cd $srcdir && pwd`
fi
PKGBUILDDIR=`pwd`

# If this is not called, install-sh will be put into .. by bootstrap.sh
# moritz, 06-26-06
AC_CONFIG_AUX_DIR(.)

AM_INIT_AUTOMAKE(nest, $GOLGIMODULE_VERSION)

# obtain host system type; HEP 2004-12-20
AC_CANONICAL_HOST

# ------------------------------------------------------------------------
# Handle options
#
# NOTE: No programs/compilations must be run in this section;
#       otherwise CFLAGS and CXXFLAGS may take on funny default
#       values.
#       HEP 2004-12-20
# ------------------------------------------------------------------------

# nest-config
NEST_CONFIG=`which nest-config`
AC_ARG_WITH(nest,[  --with-nest=script	nest-config script including path],
[
  if test "$withval" != yes; then
    NEST_CONFIG=$withval
  else
    AC_MSG_ERROR([--with-nest-config expects the nest-config script as argument. See README for details.])
  fi
])

# -------------------------------------------
# END Handle options
# -------------------------------------------

# sundials-config
SUNDIALS_CONFIG=`which sundials-config`
AC_ARG_WITH(sundials,[  --with-sundials=script	sundials-config script including path],
[
  if test "$withval" != yes; then
    SUNDIALS_CONFIG=$withval
#  else
#    AC_MSG_ERROR([--with-sundials-config expects the sundials-config script as argument. See README for details.])
  fi
])


# does nest-config work
AC_MSG_CHECKING([for nest-config ])
AC_CHECK_FILE($NEST_CONFIG, HAVE_NEST=yes, 
              AC_MSG_ERROR([No usable nest-config was found. You may want to use --with-nest-config.]))
AC_MSG_RESULT(found)

AC_MSG_CHECKING([for sundials-config ])
AC_CHECK_FILE($SUNDIALS_CONFIG, HAVE_SUNDIALS=yes, 
              AC_MSG_ERROR([No usable sundials-config was found. You may want to use --with-sundials-config.]))
AC_MSG_RESULT(found)

# the following will crash if nest-config does not run
# careful, lines below must not break
AC_MSG_CHECKING([for NEST directory information ])
NEST_PREFIX=`$NEST_CONFIG --prefix`
NEST_CPPFLAGS=`$NEST_CONFIG --cflags`
NEST_COMPILER=`$NEST_CONFIG --compiler`
if test $prefix = NONE; then prefix=`$NEST_CONFIG --prefix`; fi
AC_MSG_RESULT($NEST_CPPFLAGS)


AC_MSG_CHECKING([for SUNDIALS preprocessor flags ])
SUNDIALS_CPPFLAGS="`$SUNDIALS_CONFIG -m cvode -t s -l c -s cppflags`"
AC_MSG_RESULT($SUNDIALS_CPPFLAGS)

AC_MSG_CHECKING([for SUNDIALS linker options ])
SUNDIALS_LDFLAGS="`$SUNDIALS_CONFIG -m cvode -t s -l c -s libs` -lblas -llapack"
AC_MSG_RESULT($SUNDIALS_LDFLAGS)

# Set the platform-dependent compiler flags based on the canonical
# host string.  These flags are placed in AM_{C,CXX}FLAGS.  If
# {C,CXX}FLAGS are given as environment variables, then they are
# appended to the set of automatically chosen flags.  After
# {C,CXX}FLAGS have been read out, they must be cleared, since
# system-dependent defaults will otherwise be placed into the
# Makefiles.  HEP 2004-12-20.

# Before we can determine the proper compiler flags, we must know
# which compiler we are using.  Since the pertaining AC macros run the
# compiler and set CFLAGS, CXXFLAGS to system-dependent values, we
# need to save command line/enviroment settings of these variables
# first. AC_AIX must run before the compiler is run, so we must run it
# here.
# HEP 2004-12-21

GOLGIMODULE_SAVE_CXXFLAGS=$CXXFLAGS

# Must first check if we are on AIX
AC_AIX

# Check for C++ compiler, looking for the same compiler
# used with NEST
AC_PROG_CXX([ $NEST_COMPILER ])

# the following is makeshift, should have the macro set proper
# GOLGIMODULE_SET_CXXFLAGS
AM_CXXFLAGS=$GOLGIMODULE_SAVE_CXXFLAGS
CXXFLAGS=

## Configure C environment

AC_PROG_LD
AC_PROG_INSTALL

AC_LIBLTDL_CONVENIENCE	   ## put libltdl into a convenience library
AC_PROG_LIBTOOL		   ## use libtool
AC_CONFIG_SUBDIRS(libltdl) ## also configure subdir containing libltdl

#-- Set the language to C++
AC_LANG_CPLUSPLUS

#-- Look for programs needed in the Makefile
AC_PROG_CXXCPP
AM_PROG_LIBTOOL
AC_PATH_PROGS([MAKE],[gmake make],[make])

# ---------------------------------------------------------------
# Configure directories to be built
# ---------------------------------------------------------------

PKGDATADIR=$datadir/$PACKAGE
PKGDOCDIR=$datadir/doc/$PACKAGE

# set up directories from which to build help
# second line replaces space with colon as separator
HELPDIRS="$PKGSRCDIR $PKGSRCDIR/sli"
HELPDIRS=`echo $HELPDIRS | tr " " ":"`

#-- Replace these variables in *.in
AC_SUBST(HAVE_NEST)
AC_SUBST(NEST_CONFIG)
AC_SUBST(NEST_CPPFLAGS)
AC_SUBST(NEST_COMPILER)
AC_SUBST(NEST_PREFIX)
AC_SUBST(HELPDIRS)
AC_SUBST(PKGSRCDIR)
AC_SUBST(PKGBUILDDIR)
AC_SUBST(PKGDATADIR)
AC_SUBST(PKGDOCDIR)
AC_SUBST(KERNEL)
AC_SUBST(HOST)
AC_SUBST(SED)
AC_SUBST(LD)
AC_SUBST(host_os)
AC_SUBST(host_cpu)
AC_SUBST(host_vendor)
AC_SUBST(AS)
AC_SUBST(CXX)
AC_SUBST(AR)
AC_SUBST(ARFLAGS)
AC_SUBST(CXX_AR)
AC_SUBST(AM_CXXFLAGS)
AC_SUBST(AM_CFLAGS)
AC_SUBST(MAKE)
AC_SUBST(MAKE_FLAGS)
AC_SUBST(INCLTDL)
AC_SUBST(LIBLTDL)
AC_SUBST(SUNDIALS_CONFIG)
AC_SUBST(SUNDIALS_CPPFLAGS)
AC_SUBST(SUNDIALS_LDFLAGS)

AM_CONFIG_HEADER(golgimodule_config.h:golgimodule_config.h.in)
AC_CONFIG_FILES(Makefile)

# -----------------------------------------------
# Create output
# -----------------------------------------------
AC_OUTPUT


# -----------------------------------------------
# Report, after output at end of configure run
# Must come after AC_OUTPUT, so that it is 
# displayed after libltdl has been configured
# -----------------------------------------------

echo
echo "-------------------------------------------------------"
echo "Golgi module Configuration Summary"
echo "-------------------------------------------------------"
echo
echo "C++ compiler        : $CXX"
echo "C++ compiler flags  : $AM_CXXFLAGS"
echo "NEST compiler flags : $NEST_CPPFLAGS"
echo "SUNDIALS compiler flags : $SUNDIALS_CPPFLAGS"
echo "SUNDIALS linker flags : $SUNDIALS_LDFLAGS"

# these variables will still contain '${prefix}'
# we want to have the versions where this is resolved, too:
eval eval eval  PKGDOCDIR_AS_CONFIGURED=$PKGDOCDIR
eval eval eval  PKGDATADIR_AS_CONFIGURED=$PKGDATADIR

echo
echo "-------------------------------------------------------"
echo
echo "You can build and install Golgi module now, using"
echo "  make"
echo "  make install"
echo
echo "Golgi module will be installed to:"
echo -n "  "; eval eval echo "$libdir"
echo

EOF
)

    ("nestmodule_makefile.am" ()  
#<<EOF

# Automake file for external dynamic modules for NEST
#
# Hans Ekkehard Plesser, April 2008
# Automake file for the Developer Module
# 
# libgolgimodule is built as a normal, installable library.
# It will be installed to $prefix/lib by make install.
# 
# Headers from this directory are not to be installed upon
# make install. They are therefore included in _SOURCES.


libdir= @libdir@/nest

lib_LTLIBRARIES=      golgimodule.la libgolgimodule.la

golgimodule_la_CXXFLAGS= @AM_CXXFLAGS@
golgimodule_la_SOURCES=  golgimodule.cpp      golgimodule.h      \
                      Golgi.cpp Golgi.h \
                      drop_odd_spike_connection.h
golgimodule_la_LDFLAGS=  -module

libgolgimodule_la_CXXFLAGS= $(golgimodule_la_CXXFLAGS) -DLINKED_MODULE
libgolgimodule_la_SOURCES=  $(golgimodule_la_SOURCES)

MAKEFLAGS= @MAKE_FLAGS@

AM_CPPFLAGS= @NEST_CPPFLAGS@ \
	     @SUNDIALS_CPPFLAGS@ \
             @INCLTDL@      

AM_LDFLAGS = @SUNDIALS_LDFLAGS@

.PHONY: install-slidoc

nobase_pkgdata_DATA=\
	golgimodule.sli

install-slidoc:
	NESTRCFILENAME=/dev/null $(DESTDIR)$(NEST_PREFIX)/bin/sli --userargs="@HELPDIRS@" $(NEST_PREFIX)/share/nest/sli/install-help.sli

install-data-hook: install-exec install-slidoc

EXTRA_DIST= sli

EOF
)

    ("nestmodule.cpp" ()  
#<<EOF
/*
 *  golgimodule.cpp
 *  This file is part of NEST.
 *
 *  Copyright (C) 2008 by
 *  The NEST Initiative
 *
 *  See the file AUTHORS for details.
 *
 *  Permission is granted to compile and modify
 *  this file for non-commercial use.
 *  See the file LICENSE for details.
 *
 */

// include necessary NEST headers
//#include "config.h"
#include "network.h"
#include "model.h"
#include "dynamicloader.h"
#include "genericmodel.h"
#include "generic_connector.h"
#include "booldatum.h"
#include "integerdatum.h"
#include "tokenarray.h"
#include "exceptions.h"
#include "sliexceptions.h"
#include "nestmodule.h"

// include headers with your own stuff
#include "golgimodule.h"
#include "Golgi.h"
#include "drop_odd_spike_connection.h"

// -- Interface to dynamic module loader ---------------------------------------

/*
 * The dynamic module loader must be able to find your module. 
 * You make the module known to the loader by defining an instance of your 
 * module class in global scope. This instance must have the name
 *
 * <modulename>_LTX_mod
 *
 * The dynamicloader can then load modulename and search for symbol "mod" in it.
 */
 
golginest::GolgiModule golgimodule_LTX_mod;

// -- DynModule functions ------------------------------------------------------

golginest::GolgiModule::GolgiModule()
  { 
#ifdef LINKED_MODULE
     // register this module at the dynamic loader
     // this is needed to allow for linking in this module at compile time
     // all registered modules will be initialized by the main app's dynamic loader
     nest::DynamicLoaderModule::registerLinkedModule(this);
#endif     
   }

golginest::GolgiModule::~GolgiModule()
   {
   }

   const std::string golginest::GolgiModule::name(void) const
   {
     return std::string("Golgi Module"); // Return name of the module
   }

   const std::string golginest::GolgiModule::commandstring(void) const
   {
     /* 1. Tell interpreter that we provide the C++ part of GolgiModule with the
           current revision number. 
        2. Instruct the interpreter to check that golgimodule-init.sli exists, 
           provides at least version 1.0 of the SLI interface to GolgiModule, and
           to load it.
      */
     return std::string(
       "/golgimodule /C++ ($Revision: 8512 $) provide-component "
       "/golgimodule /SLI (7165) require-component"
       );
   }

   /* BeginDocumentation
      Name: StepPatternConnect - Connect sources and targets with a stepping pattern
      
      Synopsis:
      [sources] source_step [targets] target_step synmod StepPatternConnect -> n_connections
      
      Parameters:
      [sources]     - Array containing GIDs of potential source neurons
      source_step   - Make connection from every source_step'th neuron
      [targets]     - Array containing GIDs of potential target neurons
      target_step   - Make connection to every target_step'th neuron
      synmod        - The synapse model to use (literal, must be key in synapsedict)
      n_connections - Number of connections made
      
      Description:
      This function subsamples the source and target arrays given with steps
      source_step and target_step, beginning with the first element in each array,
      and connects the selected nodes.
      
      Example:
      /first_src 0 /network_size get def
      /last_src /iaf_neuron 20 Create def  % nodes  1 .. 20
      /src [first_src last_src] Range def
      /last_tgt /iaf_neuron 10 Create def  % nodes 21 .. 30
      /tgt [last_src 1 add last_tgt] Range def
      
      src 6 tgt 4 /drop_odd_spike StepPatternConnect 
  
      This connects nodes [1, 7, 13, 19] as sources to nodes [21, 25,
      29] as targets using synapses of type drop_odd_spike, and
      returning 12 as the number of connections.  The following
      command will print the connections (you must paste the SLI
      command as one long line):

      src { /s Set << /source s /synapse_type /static_synapse >> FindConnections { GetStatus /target get } Map dup length 0 gt { cout s <- ( -> ) <- exch <-- endl } if ; } forall
      1 -> [21 25 29]
      7 -> [21 25 29]
      13 -> [21 25 29]
      19 -> [21 25 29]
      
      Remark:
      This function is only provided as an example for how to write your own 
      interface function. 
      
      Author:
      Hans Ekkehard Plesser
      
      SeeAlso:
      Connect, ConvergentConnect, DivergentConnect
   */
   void golginest::GolgiModule::StepPatternConnect_Vi_i_Vi_i_lFunction::execute(SLIInterpreter *i) const
   {
     // Check if we have (at least) five arguments on the stack.
     i->assert_stack_load(5);

     // Retrieve source, source step, target, target step from the stack
     const TokenArray sources = getValue<TokenArray> (i->OStack.pick(4)); // bottom
     const long src_step      = getValue<long>       (i->OStack.pick(3));
     const TokenArray targets = getValue<TokenArray> (i->OStack.pick(2));
     const long tgt_step      = getValue<long>       (i->OStack.pick(1));  
     const Name synmodel_name = getValue<std::string>(i->OStack.pick(0)); // top
     
     // Obtain synapse model index
     const Token synmodel 
       = nest::NestModule::get_network().get_synapsedict().lookup(synmodel_name);
     if ( synmodel.empty() )
       throw nest::UnknownSynapseType(synmodel_name.toString());
     const nest::index synmodel_id = static_cast<nest::index>(synmodel);

     // Build a list of targets with the given step
     TokenArray selected_targets;
     for ( size_t t = 0 ; t < targets.size() ; t += tgt_step )
       selected_targets.push_back(targets[t]);
     
     // Now connect all appropriate sources to this list of targets
     size_t Nconn = 0;  // counts connections
     for ( size_t s = 0 ; s < sources.size() ; s += src_step )
     {
       // We must first obtain the GID of the source as integer
       const nest::long_t sgid = getValue<nest::long_t>(sources[s]);

       // nest::network::divergent_connect() requires weight and delay arrays. We want to use
       // default values from the synapse model, so we pass empty arrays.
       nest::NestModule::get_network().divergent_connect(sgid, selected_targets, 
							 TokenArray(), TokenArray(),
							 synmodel_id);
       Nconn += selected_targets.size();
     }

     // We get here only if none of the operations above throws and exception.
     // Now we can safely remove the arguments from the stack and push Nconn
     // as our result. 
     i->OStack.pop(5);
     i->OStack.push(Nconn);
     
     // Finally, we pop the call to this functions from the execution stack.
     i->EStack.pop();
   }

  //-------------------------------------------------------------------------------------

  void golginest::GolgiModule::init(SLIInterpreter *i, nest::Network*)
  {
    /* Register a neuron or device model.
       Give node type as template argument and the name as second argument.
       The first argument is always a reference to the network.
       Return value is a handle for later unregistration.
    */
    //printf ("before register model\n");
       nest::register_model<nest::Golgi>(nest::NestModule::get_network(), 
					    "Golgi");
       // printf ("after register model\n");

    /* Register a synapse type.
       Give synapse type as template argument and the name as second argument.
       The first argument is always a reference to the network.
    */
    nest::register_prototype_connection<DropOddSpikeConnection>(nest::NestModule::get_network(), 
                                                       "drop_odd_synapse");

    /* Register a SLI function.
       The first argument is the function name for SLI, the second a pointer to
       the function object. If you do not want to overload the function in SLI,
       you do not need to give the mangled name. If you give a mangled name, you
       should define a type trie in the golgimodule-init.sli file.
    */
    i->createcommand("StepPatternConnect_Vi_i_Vi_i_l", 
                     &stepPatternConnect_Vi_i_Vi_i_lFunction);

  }  // GolgiModule::init()

 

EOF
)

    ("nestmodule.h" ()  
#<<EOF
/*
 *  golgimodule.h
 *
 *  This file is part of NEST.
 *
 *  Copyright (C) 2008 by
 *  The NEST Initiative
 *
 *  See the file AUTHORS for details.
 *
 *  Permission is granted to compile and modify
 *  this file for non-commercial use.
 *  See the file LICENSE for details.
 *
 */

#ifndef GOLGIMODULE_H
#define GolgiMODULE_H

#include "dynmodule.h"
#include "slifunction.h"

namespace nest
{
  class Network;
}

// Put your stuff into your own namespace.
namespace golginest {
  
/**
 * Class defining your model.
 * @note For each model, you must define one such class, with a unique name.
 */
class GolgiModule : public DynModule
{
public:

  // Interface functions ------------------------------------------
  
  /**
   * @note The constructor registers the module with the dynamic loader. 
   *       Initialization proper is performed by the init() method.
   */
  GolgiModule();
  
  /**
   * @note The destructor does not do much in modules. Proper "downrigging"
   *       is the responsibility of the unregister() method.
   */
  ~GolgiModule();

  /**
   * Initialize module by registering models with the network.
   * @param SLIInterpreter* SLI interpreter
   * @param nest::Network*  Network with which to register models
   * @note  Parameter Network is needed for historical compatibility
   *        only.
   */
  void init(SLIInterpreter*, nest::Network*);

  /**
   * Return the name of your model.
   */
  const std::string name(void) const;
  
  /**
   * Return the name of a sli file to execute when golgimodule is loaded.
   * This mechanism can be used to define SLI commands associated with your
   * module, in particular, set up type tries for functions you have defined.
   */
  const std::string commandstring(void) const;
     
public:
  
  // Classes implementing your functions -----------------------------
  
  /**
   * Implement a function for a step-pattern-based connection.
   * @note What this function does is described in the SLI documentation
   *       in the cpp file.
   * @note The mangled name indicates this function expects the following
   *       arguments on the stack (bottom first): vector of int, int, 
   *       vector of int, int. 
   * @note You must define a member object in your module class
   *       of the function class. execute() is later invoked on this
   *       member.
   */
  class StepPatternConnect_Vi_i_Vi_i_lFunction: public SLIFunction
     {
     public:
       void execute(SLIInterpreter *) const;
     };

     StepPatternConnect_Vi_i_Vi_i_lFunction stepPatternConnect_Vi_i_Vi_i_lFunction;
  };
} // namespace golginest

#endif

EOF
)

    ("drop_odd_spike_connection.h" ()  
#<<EOF
#ifndef DROP_ODD_SPIKE_CONNECTION_H
#define DROP_ODD_SPIKE_CONNECTION_H

/*
 *  drop_odd_spike_connection.h
 *
 *  This file is part of NEST
 *
 *  Copyright (C) 2008 by
 *  The NEST Initiative
 *
 *  See the file AUTHORS for details.
 *
 *  Permission is granted to compile and modify
 *  this file for non-commercial use.
 *  See the file LICENSE for details.
 *
 */

#include "connection_het_wd.h"

/* BeginDocumentation
  Name: drop_odd_spike - Synapse dropping spikes with odd time stamps.

  Description:
  This synapse will not deliver any spikes with odd time stamps, while spikes with even
  time stamps go through unchanged.

  Transmits: SpikeEvent
  
  Remarks:
  This synapse type is provided only for illustration purposes in GolgiModule.

  SeeAlso: synapsedict
*/

namespace golginest {

/**
 * Connection class for illustration purposes.
 */
class DropOddSpikeConnection : public nest::ConnectionHetWD
{
 public:

  /**
   * Default Constructor.
   * Sets default values for all parameters. Needed by GenericConnectorModel.
   */
  DropOddSpikeConnection() : ConnectionHetWD() {}

  /**
   * Default Destructor.
   */
  ~DropOddSpikeConnection() {}

  /**
   * Send an event to the receiver of this connection.
   * @param e The event to send
   * @param t_lastspike Point in time of last spike sent.
   * @param cp Common properties to all synapses (empty).
   */
  void send(nest::Event& e, nest::double_t t_lastspike, 
            const nest::CommonSynapseProperties &cp);

  //! Defining this as empty means we can handle spike events
  using Connection::check_event;  // see http://www.gotw.ca/gotw/005.htm
  void check_event(nest::SpikeEvent&) {}

};


inline
void DropOddSpikeConnection::send(nest::Event& e, nest::double_t last, 
                                  const nest::CommonSynapseProperties &props)
{
  if ( e.get_stamp().get_steps() % 2 ) // stamp is odd, drop it
    return;
    
  // Even time stamp, we send the spike using the normal sending mechnism  
  // send the spike to the target
  nest::ConnectionHetWD::send(e, last, props);
}
 
} // namespace

#endif // drop_odd_spike_connection.h

EOF
)
    ("golgimodule.sli" ()  
#<<EOF
/* 
 * Initialization file for GolgiModule.
 * Run automatically when GolgiModule is loaded.
 */

M_DEBUG (golgimodule.sli) (Initializing SLI support for GolgiModule.) message

/golgimodule /SLI ($Revision: 7918 $) provide-component
/golgimodule /C++ (7165) require-component

/StepPatternConnect [ /arraytype /integertype /arraytype /integertype /literaltype ]
{ 
  StepPatternConnect_Vi_i_Vi_i_l
} def

EOF
)
    ("testrun.sli" ()  
#<<EOF
/dt 1e-3 def
(golgimodule) Install

ResetKernel
[0]
 << 
   /resolution  dt 
   /tics_per_ms  1e5
 >> SetStatus

/neuron /Golgi Create def
/vlog /voltmeter Create def
vlog neuron Connect
/vlog_parameters << /to_file true /to_memory false >> def
vlog vlog_parameters SetStatus
3000.0 Simulate

EOF
)

))